Computer Science Meets Mass Spectrometry for Proteomics |
日時:3月15日(金)16:00-16:30
会場:第1イベント会場(A棟 A201)
【講演概要】Bioinformatics involves theory, application, development of algorithms and software tools to solve problems and generate hypotheses over a wide range of biological sciences. Ever since the human genome sequencing, biology has turned from laboratory-based discipline into integration of experimental and information sciences. Bioinformatics has been contributing to biological sciences by providing software tools that can manage datasets too large or too complex to process and understand by manual analyses. In proteomics (study of active proteins in a cell), most common technologies have been built around mass spectrometry, which allows us to identify and quantify proteins, discover and characterize protein modifications in a high-throughput manner. In addition, recent studies enable elucidating protein structures and their dynamics. We have been developing various core algorithms that help us analyze mass spectrometry data. Dynamic programming approaches have been taken to sequence peptides and characterize protein modifications in an efficient manner while keeping the search space under control. Machine learning approaches helped us to optimize statistical validation processes and adapt parameter settings to experimental conditions. 【略歴】Dr. Paek received her Bachelor’s degree from Dept. of Computer Engineering, Seoul National University and did her graduate studies at Dept. of Computer Science, Stanford University, California. In her Ph. D. thesis, she provided an innovative formal model that can be used to represent causal reasoning in terms of “knowledge states” of a reasoner, where such knowledge states are represented as logical statements of first order logic, which is at the core of declarative approaches in Artificial Intelligence. |